Hepatotoxic Potential of Doxorubicin in Albino Rats

Background: Doxorubicin is an effective chemotherapeutic drug, but its toxic potential limits use. Aim: To study the effects of doxorubicin on relative tissue weight index and hepatic central vein diameter in albino rats. Study Design: Experimental Place Duration study: was conducted 20 adult rats both male female gender animal house Anatomy department, (PGMI) Lahore, Pakistan April 2019. Materials & Methods: Twenty, healthy either sex, aging 6 to 8 weeks with 180-220 g were randomly allotted two groups A B, each group having ten animals. Standard Rat feed distilled water given intraperitonially dose 1.2mg/kg/body control whereas intraperitoneally experimental twice a week for 21 days. Body along Tissue Weight Index measured gms at end experiment. Diameter (µm) assessed histologically. Results: The mean liver decreased significantly group. On contrary, all different according One-way-ANOVA test. increase drug administered commenced significant basis (p-value < 0.001) Conclusion: has effect KeyWords: Doxorubicin, Liver weight, index, Central diameter, Liver, Hepatoxicity, Albino